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    rsp-1 putative splicing factor, arginine/serine-rich 1 [ Caenorhabditis elegans ]

    Gene ID: 174748, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rsp-1
    Official Full Name
    putative splicing factor, arginine/serine-rich 1
    Primary source
    WormBase:WBGene00004698
    Locus tag
    CELE_W02B12.3
    See related
    AllianceGenome:WB:WBGene00004698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in gonad development; regulation of growth rate; and spermatogenesis. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to several human genes including SRSF5 (serine and arginine rich splicing factor 5) and SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rsp-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11453362..11455864)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein Neighboring gene putative splicing factor, arginine/serine-rich 2 Neighboring gene pseudo Neighboring gene Alanine--tRNA ligase, mitochondrial Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene Kinesin motor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development. Kawano T, et al. Mech Dev, 2000 Jul. PMID 10906451
    2. Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Longman D, et al. Genes Dev, 2007 May 1. PMID 17437990, Free PMC Article
    3. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
    4. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    5. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of growth rate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative splicing factor, arginine/serine-rich 1
    NP_001359656.1
    • Confirmed by transcript evidence
    NP_001379327.1
    • Partially confirmed by transcript evidence
    NP_496442.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11453362..11455864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064041.5 → NP_496442.1  putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23121, Q8I106, Q8I107
      Conserved Domains (3) summary
      COG0724
      Location:3 → 180
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12337
      Location:4 → 73
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:129 → 200
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

    2. NM_001373792.1 → NP_001359656.1  putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd12337
      Location:4 → 73
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:129 → 146
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001393192.1 → NP_001379327.1  putative splicing factor, arginine/serine-rich 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl17169
      Location:2 → 56
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. NR_138514.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23121.1

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