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    tni-3 Troponin I 3 [ Caenorhabditis elegans ]

    Gene ID: 180127, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tni-3
    Official Full Name
    Troponin I 3
    Primary source
    WormBase:WBGene00006585
    Locus tag
    CELE_T20B3.2
    See related
    AllianceGenome:WB:WBGene00006585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables troponin C binding activity. Involved in egg-laying behavior; muscle contraction; and post-embryonic body morphogenesis. Located in sarcomere. Is expressed in body wall musculature; non-striated muscle; rectal muscle; and in male. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tni-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (16833638..16835128, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression profiles and unc-27 mutation rescue of the striated muscle type troponin I isoform-3 in Caenorhabditis elegans. Takashima Y, et al. Genes Genet Syst, 2012. PMID 23229311
    2. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
    3. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
    4. Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system. Ono K, et al. Mol Biol Cell, 2004 Jun. PMID 15064356, Free PMC Article
    5. Genes that control ray sensory neuron axon development in the Caenorhabditis elegans male. Jia L, et al. Genetics, 2006 Jul. PMID 16624900, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TNI-3 was strongly expressed in head body-wall muscles and had an intermediated protein function among the three troponin I isoforms.
      Title: Expression profiles and unc-27 mutation rescue of the striated muscle type troponin I isoform-3 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables troponin C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in myofibril HDA PubMed 
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Troponin I 3
    NP_507250.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16833638..16835128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074849.9 → NP_507250.1  Troponin I 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5FBV4, Q9XUN9
      Conserved Domains (1) summary
      pfam00992
      Location:58 → 188
      Troponin; Troponin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUN9.1

    Gene LinkOut

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