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    unc-32 V-type proton ATPase 116 kDa subunit a 1 [ Caenorhabditis elegans ]

    Gene ID: 176257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-32
    Official Full Name
    V-type proton ATPase 116 kDa subunit a 1
    Primary source
    WormBase:WBGene00006768
    Locus tag
    CELE_ZK637.8
    See related
    AllianceGenome:WB:WBGene00006768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase binding activity. Involved in several processes, including cholinergic synaptic transmission; defense response to Gram-positive bacterium; and positive regulation of neurotransmitter secretion. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary muscle; gonad; neurons; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-32 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (8905615..8911756)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein lin-9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene thiamine pyrophosphokinase 1 Neighboring gene putative glutathione reductase 2 Neighboring gene M-phase inducer phosphatase cdc-25.3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. V-ATPase V1 sector is required for corpse clearance and neurotransmission in Caenorhabditis elegans. Ernstrom GG, et al. Genetics, 2012 Jun. PMID 22426883, Free PMC Article
    2. Functional study of the Caenorhabditis elegans secretory-excretory system using laser microsurgery. Nelson FK, et al. J Exp Zool, 1984 Jul. PMID 6470649
    3. The C. elegans genome sequencing project: a beginning. Sulston J, et al. Nature, 1992 Mar 5. PMID 1538779
    4. Neither maternal nor zygotic med-1/med-2 genes play a major role in specifying the Caenorhabditis elegans endoderm. Captan VV, et al. Genetics, 2007 Feb. PMID 17151237, Free PMC Article
    5. The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit. Pujol N, et al. J Biol Chem, 2001 Apr 13. PMID 11110798

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase.
      Title: Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase.
    2. Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene.
      Title: CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of locomotion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase 116 kDa subunit a 1
    NP_001023017.1
    • Confirmed by transcript evidence
    NP_001023018.1
    • Confirmed by transcript evidence
    NP_001023019.1
    • Confirmed by transcript evidence
    NP_001023020.1
    • Confirmed by transcript evidence
    NP_001023021.1
    • Confirmed by transcript evidence
    NP_001023022.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8905615..8911756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027849.4 → NP_001023020.1  V-type proton ATPase 116 kDa subunit a 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30628
      Conserved Domains (2) summary
      COG1269
      Location:40 → 886
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:40 → 885
      V_ATPase_I; V-type ATPase 116kDa subunit family

    2. NM_001027847.4 → NP_001023018.1  V-type proton ATPase 116 kDa subunit a 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30628
      Conserved Domains (2) summary
      COG1269
      Location:40 → 870
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:40 → 869
      V_ATPase_I; V-type ATPase 116kDa subunit family

    3. NM_001027850.5 → NP_001023021.1  V-type proton ATPase 116 kDa subunit a 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30628
      Conserved Domains (2) summary
      COG1269
      Location:40 → 875
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:40 → 874
      V_ATPase_I; V-type ATPase 116kDa subunit family

    4. NM_001027846.2 → NP_001023017.1  V-type proton ATPase 116 kDa subunit a 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023017.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30628, Q23555, Q9GPJ3, Q9GPJ4, Q9GPJ5, Q9GPJ6, Q9GPJ7, Q9GPJ8
      Conserved Domains (2) summary
      COG1269
      Location:40 → 892
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:40 → 891
      V_ATPase_I; V-type ATPase 116kDa subunit family

    5. NM_001027851.2 → NP_001023022.1  V-type proton ATPase 116 kDa subunit a 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30628
      Conserved Domains (2) summary
      COG1269
      Location:40 → 876
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:40 → 875
      V_ATPase_I; V-type ATPase 116kDa subunit family

    6. NM_001027848.7 → NP_001023019.1  V-type proton ATPase 116 kDa subunit a 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023019.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30628
      Conserved Domains (2) summary
      COG1269
      Location:40 → 881
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:40 → 880
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30628.3

    Gene LinkOut

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