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    trm-1 tRNA (guanine(26)-N(2))-dimethyltransferase [ Caenorhabditis elegans ]

    Gene ID: 179920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trm-1
    Official Full Name
    tRNA (guanine(26)-N(2))-dimethyltransferase
    Primary source
    WormBase:WBGene00006613
    Locus tag
    CELE_ZC376.5
    See related
    AllianceGenome:WB:WBGene00006613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tRNA (guanine(10)-N2)-methyltransferase activity; tRNA (guanine(26)-N2)-dimethyltransferase activity; and tRNA binding activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trm-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (14183124..14185609, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Homeobox domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene INTegrator complex Subunit homolog Neighboring gene Stress activated transcription factor atfs-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity. Liu J, et al. Gene, 1999 Jan 8. PMID 10048958
    2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(26)-N(2))-dimethyltransferase
    NP_001379156.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14183124..14185609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392650.1 → NP_001379156.1  tRNA (guanine(26)-N(2))-dimethyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23270
      Conserved Domains (1) summary
      pfam02005
      Location:9 → 442
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23270.1

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