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    unc-31 Calcium-dependent secretion activator;PH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-31
    Official Full Name
    Calcium-dependent secretion activator;PH domain-containing protein
    Primary source
    WormBase:WBGene00006767
    Locus tag
    CELE_ZK897.1
    See related
    AllianceGenome:WB:WBGene00006767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to carbon dioxide; egg-laying behavior; and signal release. Located in several cellular components, including axon; dense core granule; and neuronal cell body. Is expressed in several structures, including egg-laying apparatus; excretory gland cell; nervous system; postcloacal sensillum; and rectal gland cell. Orthologous to several human genes including CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-31 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    23
    Sequence:
    Chromosome: IV; NC_003282.8 (12773867..12788354)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF1793 domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability. Dallière N, et al. FASEB J, 2016 Feb. PMID 26514165, Free PMC Article
    2. The C(2) and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca(2+)-regulated exocytosis. Zhang L, et al. Structure, 2023 Apr 6. PMID 36863339
    3. UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons. Lin XG, et al. Biochem Biophys Res Commun, 2010 Jul 2. PMID 20515653
    4. Caenorhabditis elegans Male Copulation Circuitry Incorporates Sex-Shared Defecation Components To Promote Intromission and Sperm Transfer. LeBoeuf B, et al. G3 (Bethesda), 2017 Feb 9. PMID 28031243, Free PMC Article
    5. The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Avery L, et al. Genetics, 1993 Jun. PMID 8325482, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Four UNC-31 domains support distinct sequential molecular actions of UNC-31 in vesicular exocytosis, including steps in vesicle tethering and docking that bridge vesicle with plasma membrane.
      Title: UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons.
    2. CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations.
      Title: CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons.
    3. UNC-31 is required for the docking of DCVs at the plasma membrane. Interestingly, the defect in DCV docking caused by UNC-31 mutation can be fully rescued by PKA activation.
      Title: PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons.
    4. Calcium activated protein for secretion (CAPS)/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system.
      Title: UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to carbon dioxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dense core granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of anterior/posterior axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in serotonin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventral cord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calcium-dependent secretion activator;PH domain-containing protein
    NP_001255663.1
    • Confirmed by transcript evidence
    NP_001255664.1
    • Confirmed by transcript evidence
    NP_001255665.1
    • Confirmed by transcript evidence
    NP_001255666.1
    • Confirmed by transcript evidence
    NP_001255667.1
    • Confirmed by transcript evidence
    NP_001255668.1
    • Confirmed by transcript evidence
    NP_001255669.1
    • Confirmed by transcript evidence
    NP_001255670.1
    • Confirmed by transcript evidence
    NP_001255671.1
    • Confirmed by transcript evidence
    NP_001293901.1
    • Confirmed by transcript evidence
    NP_001293902.1
    • Confirmed by transcript evidence
    NP_001293903.1
    • Confirmed by transcript evidence
    NP_001293904.1
    • Confirmed by transcript evidence
    NP_001293905.1
    • Confirmed by transcript evidence
    NP_001293906.1
    • Confirmed by transcript evidence
    NP_001293907.1
    • Confirmed by transcript evidence
    NP_001293908.1
    • Confirmed by transcript evidence
    NP_001293909.1
    • Confirmed by transcript evidence
    NP_001293910.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12773867..12788354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268737.4 → NP_001255666.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23658
      Conserved Domains (4) summary
      cd01234
      Location:575 → 697
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:582 → 685
      PH; PH domain
      pfam06292
      Location:894 → 985
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:463 → 577
      C2; C2 domain

    2. NM_001268738.4 → NP_001255667.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23658
      Conserved Domains (4) summary
      cd01234
      Location:563 → 685
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:570 → 673
      PH; PH domain
      pfam06292
      Location:882 → 973
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:451 → 565
      C2; C2 domain

    3. NM_001268735.4 → NP_001255664.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1P637, D3YT40, D3YT41, D3YT42, D3YT43, Q23658
      Conserved Domains (4) summary
      cd01234
      Location:563 → 685
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:570 → 673
      PH; PH domain
      pfam06292
      Location:882 → 973
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:451 → 565
      C2; C2 domain

    4. NM_001306972.3 → NP_001293901.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKP8
      Conserved Domains (4) summary
      cd01234
      Location:582 → 704
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:589 → 692
      PH; PH domain
      pfam06292
      Location:901 → 996
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:470 → 584
      C2; C2 domain

    5. NM_001306973.3 → NP_001293902.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACM4
      Conserved Domains (4) summary
      cd01234
      Location:582 → 704
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:589 → 692
      PH; PH domain
      pfam06292
      Location:901 → 992
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:470 → 584
      C2; C2 domain

    6. NM_001306974.3 → NP_001293903.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADT8
      Conserved Domains (4) summary
      cd01234
      Location:575 → 697
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:582 → 685
      PH; PH domain
      pfam06292
      Location:894 → 989
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:463 → 577
      C2; C2 domain

    7. NM_001306975.3 → NP_001293904.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACJ2
      Conserved Domains (4) summary
      cd01234
      Location:575 → 697
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:582 → 685
      PH; PH domain
      pfam06292
      Location:894 → 985
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:463 → 577
      C2; C2 domain

    8. NM_001306976.3 → NP_001293905.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJ06
      Conserved Domains (4) summary
      cd01234
      Location:563 → 685
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:570 → 673
      PH; PH domain
      pfam06292
      Location:882 → 977
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:451 → 565
      C2; C2 domain

    9. NM_001306977.3 → NP_001293906.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKQ5
      Conserved Domains (4) summary
      cd01234
      Location:563 → 685
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:570 → 673
      PH; PH domain
      pfam06292
      Location:882 → 973
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:451 → 565
      C2; C2 domain

    10. NM_001306978.3 → NP_001293907.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACM9
      Conserved Domains (4) summary
      cd01234
      Location:570 → 692
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:577 → 680
      PH; PH domain
      pfam06292
      Location:889 → 984
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:458 → 572
      C2; C2 domain

    11. NM_001268734.3 → NP_001255663.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2V2
      Conserved Domains (4) summary
      cd01234
      Location:570 → 692
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:577 → 680
      PH; PH domain
      pfam06292
      Location:889 → 980
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:458 → 572
      C2; C2 domain

    12. NM_001306979.3 → NP_001293908.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADU4
      Conserved Domains (4) summary
      cd01234
      Location:563 → 685
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:570 → 673
      PH; PH domain
      pfam06292
      Location:882 → 977
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:451 → 565
      C2; C2 domain

    13. NM_001306980.3 → NP_001293909.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACJ8
      Conserved Domains (4) summary
      cd01234
      Location:551 → 673
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:558 → 661
      PH; PH domain
      pfam06292
      Location:870 → 965
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:439 → 553
      C2; C2 domain

    14. NM_001268736.3 → NP_001255665.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2V3
      Conserved Domains (4) summary
      cd01234
      Location:551 → 673
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:558 → 661
      PH; PH domain
      pfam06292
      Location:870 → 961
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:439 → 553
      C2; C2 domain

    15. NM_001306981.3 → NP_001293910.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJ13
      Conserved Domains (4) summary
      cd01234
      Location:115 → 237
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:122 → 225
      PH; PH domain
      pfam06292
      Location:434 → 529
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:3 → 117
      C2; C2 domain

    16. NM_001268739.3 → NP_001255668.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23658
      Conserved Domains (4) summary
      cd01234
      Location:115 → 237
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:122 → 225
      PH; PH domain
      pfam06292
      Location:434 → 525
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:3 → 117
      C2; C2 domain

    17. NM_001268740.3 → NP_001255669.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255669.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23658
      Conserved Domains (4) summary
      cd01234
      Location:115 → 237
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:122 → 225
      PH; PH domain
      pfam06292
      Location:434 → 525
      DUF1041; Domain of Unknown Function (DUF1041)
      cl14603
      Location:3 → 117
      C2; C2 domain

    18. NM_001268741.3 → NP_001255670.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255670.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU01

    19. NM_001268742.1 → NP_001255671.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23658
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23658.6

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