pycr-1 pyrroline-5-carboxylate reductase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pycr-1
Official Full Name: pyrroline-5-carboxylate reductase
Primary source: WormBase:WBGene00010924
Locus tag: CELE_M153.1
See related: AllianceGenome:WB:WBGene00010924
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to several human genes including PYCR1 (pyrroline-5-carboxylate reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables pyrroline-5-carboxylate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrroline-5-carboxylate reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proline biosynthetic process	IEA Inferred from Electronic Annotation more info

NP_001348640.1

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