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    icd-1 Transcription factor BTF3 homolog [ Caenorhabditis elegans ]

    Gene ID: 174090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    icd-1
    Official Full Name
    Transcription factor BTF3 homolog
    Primary source
    WormBase:WBGene00002045
    Locus tag
    CELE_C56C10.8
    See related
    AllianceGenome:WB:WBGene00002045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in embryo development and negative regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including germ line; intestine; pharynx; preanal ganglion; and somatic nervous system. Orthologous to human BTF3 (basic transcription factor 3) and BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See icd-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (6587577..6588655, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene putative trafficking protein particle complex subunit 13 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Charged multivesicular body protein 4b Neighboring gene 45 kDa calcium-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC. Gamerdinger M, et al. Mol Cell, 2019 Sep 5. PMID 31377116
    2. Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins. Martin EM, et al. J Biol Chem, 2018 Jun 1. PMID 29650757, Free PMC Article
    3. The nascent polypeptide-associated complex is essential for autophagic flux. Guo B, et al. Autophagy, 2014 Oct 1. PMID 25126725, Free PMC Article
    4. Mechanosensitive Ion Channels in Caenorhabditis elegans. Bazopoulou D, et al. Curr Top Membr, 2007. PMID 25168133
    5. Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans. Bloss TA, et al. Nature, 2003 Aug 28. PMID 12944970

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans inhibitor of cell death-1 (ICD-1) is necessary and sufficient to prevent apoptosis [ICD-1]
      Title: Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nascent polypeptide-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor BTF3 homolog
    NP_495336.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6587577..6588655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062935.10 → NP_495336.1  Transcription factor BTF3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18885
      Conserved Domains (1) summary
      pfam01849
      Location:45 → 96
      NAC; NAC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18885.1

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