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    vha-4 V-type proton ATPase 21 kDa proteolipid subunit c'' [ Caenorhabditis elegans ]

    Gene ID: 174272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vha-4
    Official Full Name
    V-type proton ATPase 21 kDa proteolipid subunit c''
    Primary source
    WormBase:WBGene00006913
    Locus tag
    CELE_T01H3.1
    See related
    AllianceGenome:WB:WBGene00006913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton transmembrane transporter activity. Involved in embryo development. Predicted to be part of proton-transporting two-sector ATPase complex, proton-transporting domain. Predicted to be active in membrane. Is expressed in excretory cell and rectum. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vha-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (7878082..7879316, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene Peroxin/Ferlin domain-containing protein Neighboring gene ncRNA Neighboring gene XH domain-containing protein Neighboring gene Epimerase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans. Oka T, et al. J Biol Chem, 2000 Sep 22. PMID 10846178
    2. Three vha genes encode proteolipids of Caenorhabditis elegans vacuolar-type ATPase. Gene structures and preferential expression in an H-shaped excretory cell and rectal cells. Oka T, et al. J Biol Chem, 1997 Sep 26. PMID 9305897
    3. Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cell-specific distribution. Oka T, et al. J Biol Chem, 1998 Aug 28. PMID 9712884
    4. Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. Oka T, et al. J Biol Chem, 2001 Aug 31. PMID 11441002
    5. The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. Liégeois S, et al. J Cell Biol, 2006 Jun 19. PMID 16785323, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase 21 kDa proteolipid subunit c''
    NP_495659.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7878082..7879316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063258.9 → NP_495659.1  V-type proton ATPase 21 kDa proteolipid subunit c'' [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDB8
      Conserved Domains (1) summary
      pfam00137
      Location:54 → 114
      ATP-synt_C; ATP synthase subunit C
    Nucleotide Protein
    Heading Accession and Version

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