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    dhs-25 Estradiol 17-beta-dehydrogenase 8 [ Caenorhabditis elegans ]

    Gene ID: 180486, updated on 27-Dec-2024

    Summary

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    Official Symbol
    dhs-25
    Official Full Name
    Estradiol 17-beta-dehydrogenase 8
    Primary source
    WormBase:WBGene00000988
    Locus tag
    CELE_F09E10.3
    See related
    AllianceGenome:WB:WBGene00000988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and quinone binding activity. Predicted to be involved in fatty acid biosynthetic process. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-25 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (1486532..1489326)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene Globin family profile domain-containing protein Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast. Gurvitz A. J Biomed Biotechnol, 2009. PMID 19746209, Free PMC Article
    2. Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38517909, Free PMC Article
    3. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Estradiol 17-beta-dehydrogenase 8
    NP_508282.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1486532..1489326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075881.7 → NP_508282.2  Estradiol 17-beta-dehydrogenase 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508282.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19246
      Conserved Domains (2) summary
      cd05333
      Location:8 → 245
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
      PRK05653
      Location:4 → 248
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    Nucleotide Protein
    Heading Accession and Version

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