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    alh-3 10-formyltetrahydrofolate dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 177999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alh-3
    Official Full Name
    10-formyltetrahydrofolate dehydrogenase
    Primary source
    WormBase:WBGene00000109
    Locus tag
    CELE_F36H1.6
    See related
    AllianceGenome:WB:WBGene00000109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Predicted to be located in cytoplasm. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1) and ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alh-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (11022603..11025870)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mannosyl-oligosaccharide glucosidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC transporter permease;Small subunit of serine palmitoyltransferase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development. Minogue AL, et al. Nat Commun, 2018 Dec 14. PMID 30552320, Free PMC Article
    2. The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans. Shaw WR, et al. Genetics, 2010 Jul. PMID 20421599, Free PMC Article
    3. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. Miska EA, et al. PLoS Genet, 2007 Dec. PMID 18085825, Free PMC Article
    4. Many families of C. elegans microRNAs are not essential for development or viability. Alvarez-Saavedra E, et al. Curr Biol, 2010 Feb 23. PMID 20096582, Free PMC Article
    5. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formyltetrahydrofolate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formyltetrahydrofolate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    10-formyltetrahydrofolate dehydrogenase
    NP_502054.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11022603..11025870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069653.9 → NP_502054.2  10-formyltetrahydrofolate dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502054.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECV9
      Conserved Domains (5) summary
      cd08647
      Location:1 → 209
      FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
      cd08703
      Location:214 → 315
      FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
      TIGR00460
      Location:1 → 318
      fmt; methionyl-tRNA formyltransferase
      pfam00550
      Location:335 → 393
      PP-binding; Phosphopantetheine attachment site
      cl11961
      Location:423 → 908
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein
    Heading Accession and Version

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