tbg-1 Tubulin gamma chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tbg-1
Official Full Name: Tubulin gamma chain
Primary source: WormBase:WBGene00006540
Locus tag: CELE_F58A4.8
See related: AllianceGenome:WB:WBGene00006540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including detection of temperature stimulus; maintenance of centrosome location; and microtubule cytoskeleton organization. Located in centrosome and cytoplasm. Is expressed in gonad. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tbg-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (9626536..9629154, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that NOCA-1 acts with gamma-tubulin to assemble non-centrosomal arrays in multiple tissues and highlight functional overlap between the ninein and Patronin protein families.
Title: NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.
Data show expression of tbg-1 during the development revealed differential expression in different developmental stages and that gamma-tubulin expression was observed through out the development from embryonic and post-embryonic stages.
Title: Expression of gamma-tubulin during the development of nematode Caenorhabditis elegans.
Gamma-tubulin in the PCM stabilizes the nascent daughter centriole by promoting microtubule addition to its outer wall. Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM.
Title: SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58A4.9 (e-PCR)
- UniSTS:320569

F58A4.8 (e-PCR)
- UniSTS:314519

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables microtubule nucleator activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of centrosome location	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cytokinetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin complex	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	IBA Inferred from Biological aspect of Ancestor more info
located_in hemidesmosome	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tubulin gamma chain

NP_499131.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9626536..9629154 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066730.9 → NP_499131.1 Tubulin gamma chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499131.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34475

Conserved Domains (2) summary

PLN00222
Location:7 → 443

PLN00222; tubulin gamma chain; Provisional

cd02188
Location:5 → 431

gamma_tubulin; The gamma-tubulin family