crp-1 Cdc-42 Related Protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crp-1
Official Full Name: Cdc-42 Related Protein
Primary source: WormBase:WBGene00012532
Locus tag: CELE_Y32F6B.3
See related: AllianceGenome:WB:WBGene00012532
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Located in recycling endosome and trans-Golgi network. Is expressed in several structures, including excretory cell; pharyngeal-intestinal valve; rectal epithelium; socket cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See crp-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (10478564..10480964)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

function for Cdc42-related protein (CRP-1) in the regulation of membrane trafficking in a subset of cells with epithelial characteristics
Title: Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y32F6B.3 (e-PCR)
- UniSTS:318652

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Cdc-42 Related Protein

NP_505688.1

Product from WormBase gene class crp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10478564..10480964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073287.7 → NP_505688.1 Cdc-42 Related Protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505688.1

Status: REVIEWED

UniProtKB/TrEMBL

O62422

Conserved Domains (2) summary

smart00174
Location:7 → 171

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd00157
Location:5 → 169

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)