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    eef-1G putative elongation factor 1-gamma [ Caenorhabditis elegans ]

    Gene ID: 179522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eef-1G
    Official Full Name
    putative elongation factor 1-gamma
    Primary source
    WormBase:WBGene00008920
    Locus tag
    CELE_F17C11.9
    See related
    AllianceGenome:WB:WBGene00008920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be active in cytoplasm and nucleus. Used to study cardiovascular system disease. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eef-1G in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (10965719..10967922)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Minichromosome loss protein Mcl1 middle region domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene C6 domain-containing protein;ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative proteomic analysis reveals differentially expressed proteins in Caenorhabditis elegans pgl-1 mutants grown at 20°C and 25°C. Tohsato Y, et al. J Proteomics, 2012 Aug 3. PMID 22579749
    2. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann MC, et al. PLoS Genet, 2016 May. PMID 27138431, Free PMC Article
    3. A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research. Ray AK, et al. Sci Rep, 2024 Mar 29. PMID 38553458, Free PMC Article
    4. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Hayes GD, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381276
    5. Analysis of acidic peptides with a matrix-assisted laser desorption/ionization mass spectrometry using positive and negative ion modes with additive monoammonium phosphate. Nabetani T, et al. Proteomics, 2006 Aug. PMID 16897684

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative elongation factor 1-gamma
    NP_001041100.1
    • Confirmed by transcript evidence
    NP_001379321.1
    • Partially confirmed by transcript evidence
    NP_505800.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10965719..10967922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073399.7 → NP_505800.1  putative elongation factor 1-gamma [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54412, Q2PJ76, Q8I4K9
      Conserved Domains (4) summary
      cd03181
      Location:71 → 188
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      COG0625
      Location:4 → 181
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03044
      Location:3 → 77
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:238 → 343
      EF1G; Elongation factor 1 gamma, conserved domain

    2. NM_001392606.1 → NP_001379321.1  putative elongation factor 1-gamma [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd03181
      Location:46 → 163
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      pfam00647
      Location:215 → 318
      EF1G; Elongation factor 1 gamma, conserved domain

    3. NM_001047635.7 → NP_001041100.1  putative elongation factor 1-gamma [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54412
      Conserved Domains (3) summary
      cd03044
      Location:3 → 77
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:205 → 310
      EF1G; Elongation factor 1 gamma, conserved domain
      cl02776
      Location:71 → 155
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54412.1

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