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    gcy-20 Receptor-type guanylate cyclase gcy-20 [ Caenorhabditis elegans ]

    Gene ID: 184797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-20
    Official Full Name
    Receptor-type guanylate cyclase gcy-20
    Primary source
    WormBase:WBGene00001545
    Locus tag
    CELE_F21H7.9
    See related
    AllianceGenome:WB:WBGene00001545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in ASEL; AWCL; AWCR; excretory canal; and excretory gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-20 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (16248583..16253787, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog Neighboring gene Nuclear hormone receptor family member nhr-218 Neighboring gene Nuclear hormone receptor family member nhr-127

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold. Li R, et al. Cell Rep, 2024 Feb 27. PMID 38294902
    2. Cis-regulatory mechanisms of left/right asymmetric neuron-subtype specification in C. elegans. Etchberger JF, et al. Development, 2009 Jan. PMID 19060335, Free PMC Article
    3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
    4. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article
    5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-20
    NP_507101.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16248583..16253787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074700.1 → NP_507101.1  Receptor-type guanylate cyclase gcy-20 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507101.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62179
      Conserved Domains (7) summary
      cd06352
      Location:22 → 439
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:840 → 1032
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      smart00221
      Location:562 → 801
      STYKc; Protein kinase; unclassified specificity
      pfam00211
      Location:867 → 1054
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:44 → 418
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:818 → 861
      HNOBA; Heme NO binding associated
      cl21453
      Location:536 → 801
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62179.2

    Gene LinkOut

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