rad-23 UV excision repair protein RAD23 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rad-23
Official Full Name: UV excision repair protein RAD23
Primary source: WormBase:WBGene00013924
Locus tag: CELE_ZK20.3
See related: AllianceGenome:WB:WBGene00013924
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol and nucleoplasm. Is expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Orthologous to several human genes including RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rad-23 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (11651262..11652729, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that reducing RAD-23 abundance protects against the toxicity of two misfolding-prone proteins that cause amyotrophic lateral sclerosis.
Title: Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.
Authors show a developmental role for a PNGase and Rad-23 in the regulation of neuronal branching during organ innervation.
Title: The N-glycanase png-1 acts to limit axon branching during organ formation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK20.3 (e-PCR)
- UniSTS:306558

ZK20.5 (e-PCR)
- UniSTS:310454

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UV excision repair protein RAD23

NP_496488.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11651262..11652729 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064087.9 → NP_496488.2 UV excision repair protein RAD23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496488.2

Status: REVIEWED

UniProtKB/TrEMBL

Q23451

Conserved Domains (5) summary

cd01805
Location:3 → 79

RAD23_N; Ubiquitin-like domain of RAD23

cd14280
Location:128 → 166

UBA1_Rad23_like; UBA1 domain of Rad23 proteins found in eukaryotes

TIGR00601
Location:3 → 319

rad23; UV excision repair protein Rad23

pfam09280
Location:196 → 248

XPC-binding; XPC-binding domain

cl21463
Location:278 → 318

UBA_like_SF; UBA domain-like superfamily