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    • Showing Current items.

    uncp-18 Syntaxin-binding protein 1 [ Caenorhabditis elegans ]

    Gene ID: 176862, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uncp-18
    Official Full Name
    Syntaxin-binding protein 1
    Primary source
    WormBase:WBGene00020298
    Locus tag
    CELE_T07A9.10
    See related
    AllianceGenome:WB:WBGene00020298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable syntaxin binding activity. Predicted to be involved in intracellular protein transport; presynaptic dense core vesicle exocytosis; and vesicle docking involved in exocytosis. Predicted to be located in presynapse. Predicted to be active in plasma membrane and secretory granule. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 5. Orthologous to human STXBP2 (syntaxin binding protein 2) and STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uncp-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (390560..393158)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein eS24 Neighboring gene Sjogren's Syndrome Nuclear Autoantigen Neighboring gene Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial Neighboring gene Cytochrome c oxidase assembly protein COX14 Neighboring gene Nucleolar GTP-binding protein 1 Neighboring gene Ribosomal RNA-processing protein 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18. Boeglin M, et al. Genetics, 2023 Dec 6. PMID 37793339, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic dense core vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Syntaxin-binding protein 1
    NP_499918.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      390560..393158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067517.7 → NP_499918.1  Syntaxin-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44412
      Conserved Domains (1) summary
      pfam00995
      Location:31 → 547
      Sec1; Sec1 family
    Nucleotide Protein
    Heading Accession and Version

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