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    adt-1 A disintegrin and metalloproteinase with thrombospondin motifs adt-1;Peptidase M12B domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adt-1
    Official Full Name
    A disintegrin and metalloproteinase with thrombospondin motifs adt-1;Peptidase M12B domain-containing protein
    Primary source
    WormBase:WBGene00000082
    Locus tag
    CELE_C02B4.1
    See related
    AllianceGenome:WB:WBGene00000082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including amphid neurons; body wall musculature; pharyngeal muscle cell; ventral nerve cord; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See adt-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    28
    Sequence:
    Chromosome: X; NC_003284.9 (12678832..12689279)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative UDP-glucuronosyltransferase ugt-50;UDP-glucuronosyltransferase;glucuronosyltransferase Neighboring gene ncRNA Neighboring gene Nuclear receptor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs adt-1;Peptidase M12B domain-containing protein
    NP_001361951.1
    • Partially confirmed by transcript evidence
    NP_510116.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12678832..12689279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077715.5 → NP_510116.2  A disintegrin and metalloproteinase with thrombospondin motifs adt-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510116.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECS8
      Conserved Domains (5) summary
      smart00209
      Location:1327 → 1378
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:234 → 448
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      PTZ00441
      Location:762 → 806
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      pfam01562
      Location:64 → 163
      Pep_M12B_propep; Reprolysin family propeptide
      cl15278
      Location:1088 → 1135
      TSP_1; Thrombospondin type 1 domain

    2. NM_001375156.2 → NP_001361951.1  Peptidase M12B domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22580
      Conserved Domains (5) summary
      smart00209
      Location:1324 → 1375
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:231 → 445
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      PTZ00441
      Location:759 → 803
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      pfam01562
      Location:64 → 163
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:463 → 531
      ADAM_CR_2; ADAM cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECS8.1

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