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    asfl-1 putative histone chaperone asf-1-like protein [ Caenorhabditis elegans ]

    Gene ID: 172812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asfl-1
    Official Full Name
    putative histone chaperone asf-1-like protein
    Primary source
    WormBase:WBGene00007277
    Locus tag
    CELE_C03D6.5
    See related
    AllianceGenome:WB:WBGene00007277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone binding activity. Involved in several processes, including oogenesis; regulation of brood size; and spermatogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in intestine. Orthologous to several human genes including ASF1A (anti-silencing function 1A histone chaperone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asfl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (9658274..9660080)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene protein-disulfide reductase Neighboring gene Long arms of the bivalent protein 1 Neighboring gene Aa_trans domain-containing protein Neighboring gene Nuclear pore complex protein 14 Neighboring gene mRNA guanylyltransferase Neighboring gene Piwi domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional redundancy of two C. elegans homologs of the histone chaperone Asf1 in germline DNA replication. Grigsby IF, et al. Dev Biol, 2009 May 1. PMID 19233156
    2. LAB-1 antagonizes the Aurora B kinase in C. elegans. de Carvalho CE, et al. Genes Dev, 2008 Oct 15. PMID 18923084, Free PMC Article
    3. Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans. Nakano S, et al. Cell, 2011 Dec 23. PMID 22177093, Free PMC Article
    4. HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity. Sural S, et al. Sci Adv, 2020 Oct. PMID 33087356, Free PMC Article
    5. The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells. Lin B, et al. Dev Biol, 2008 Apr 1. PMID 18304523, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional redundancy of two C. elegans homologs of the histone chaperone Asfl-1 in germline DNA replication is reported.
      Title: Functional redundancy of two C. elegans homologs of the histone chaperone Asf1 in germline DNA replication.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of brood size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative histone chaperone asf-1-like protein
    NP_492567.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9658274..9660080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060166.9 → NP_492567.3  putative histone chaperone asf-1-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492567.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17603
      Conserved Domains (1) summary
      pfam04729
      Location:3 → 154
      ASF1_hist_chap; ASF1 like histone chaperone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17603.4

    Gene LinkOut

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