wdfy-2 WD repeat and FYVE domain-containing protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wdfy-2
Official Full Name: WD repeat and FYVE domain-containing protein 2
Primary source: WormBase:WBGene00008402
Locus tag: CELE_D2013.2
See related: AllianceGenome:WB:WBGene00008402
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in endocytosis. Predicted to be active in early endosome. Orthologous to human WDFY1 (WD repeat and FYVE domain containing 1) and WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wdfy-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (9319865..9321878)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2013.3 (e-PCR)
- UniSTS:307400

D2013.2 (e-PCR)
- UniSTS:309477

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat and FYVE domain-containing protein 2

NP_495983.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9319865..9321878

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063582.4 → NP_495983.1 WD repeat and FYVE domain-containing protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18964

Conserved Domains (4) summary

COG2319
Location:26 → 289

WD40; WD40 repeat [General function prediction only]

cd15718
Location:284 → 353

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:124 → 163

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 281

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...