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    anp-1 Aminopeptidase [ Caenorhabditis elegans ]

    Gene ID: 179763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    anp-1
    Official Full Name
    Aminopeptidase
    Primary source
    WormBase:WBGene00011587
    Locus tag
    CELE_T07F10.1
    See related
    AllianceGenome:WB:WBGene00011587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables metalloaminopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in excretory cell; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to several human genes including ANPEP (alanyl aminopeptidase, membrane); ERAP1 (endoplasmic reticulum aminopeptidase 1); and ERAP2 (endoplasmic reticulum aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See anp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (12859444..12863837)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein;Transmembrane protein Neighboring gene DUF19 domain-containing protein Neighboring gene BRCT domain-containing protein Neighboring gene RRM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans. Su S, et al. PeerJ, 2019. PMID 31737443, Free PMC Article
    2. Assessment of Caenorhabditis elegans as a model in Haemonchus contortus vaccine research. Geldhof P, et al. Mol Biochem Parasitol, 2007 Apr. PMID 17234278
    3. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Mohandas N, et al. Biotechnol Adv, 2016 Mar-Apr. PMID 26597954
    4. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article
    5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aminopeptidase
    NP_001041160.1
    • Confirmed by transcript evidence
    NP_001041161.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12859444..12863837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047695.5 → NP_001041160.1  Aminopeptidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22317
      Conserved Domains (3) summary
      cd09601
      Location:93 → 559
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:85 → 486
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:632 → 964
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_001047696.3 → NP_001041161.1  Aminopeptidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1HB04
      Conserved Domains (3) summary
      cd09601
      Location:81 → 547
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:73 → 474
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:620 → 952
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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