mel-32 Serine hydroxymethyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mel-32
Official Full Name: Serine hydroxymethyltransferase
Primary source: WormBase:WBGene00003214
Locus tag: CELE_C05D11.11
See related: AllianceGenome:WB:WBGene00003214
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glycine hydroxymethyltransferase activity and pyridoxal phosphate binding activity. Involved in embryo development. Located in mitochondrion. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in breast cancer and neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities. Orthologous to several human genes including SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mel-32 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (6440148..6442815, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D11.11 (e-PCR)
- UniSTS:308476

C05D11.13 (e-PCR)
- UniSTS:308477

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glycine hydroxymethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine hydroxymethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine hydroxymethyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	TAS Traceable Author Statement more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in serine family amino acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine hydroxymethyltransferase

NP_001379624.1

Confirmed by transcript evidence

NP_741197.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6440148..6442815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392122.1 → NP_001379624.1 Serine hydroxymethyltransferase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03226
Location:28 → 480

PLN03226; serine hydroxymethyltransferase; Provisional
NM_171169.6 → NP_741197.1 Serine hydroxymethyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741197.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P50432, Q95QX8

Conserved Domains (2) summary

PLN03226
Location:51 → 503

PLN03226; serine hydroxymethyltransferase; Provisional

cl18945
Location:52 → 450

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...