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    hsp-75 Histidine kinase/HSP90-like ATPase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hsp-75
    Official Full Name
    Histidine kinase/HSP90-like ATPase domain-containing protein
    Primary source
    WormBase:WBGene00020110
    Locus tag
    CELE_R151.7
    See related
    AllianceGenome:WB:WBGene00020110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human TRAP1 (TNF receptor associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hsp-75 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (7223233..7226707, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Derlin-2 Neighboring gene Myb-like domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes. Hough RF, et al. Nucleic Acids Res, 1999 Sep 1. PMID 10446229, Free PMC Article
    2. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. Birnby DA, et al. Genetics, 2000 May. PMID 10790386, Free PMC Article
    3. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histidine kinase/HSP90-like ATPase domain-containing protein
    NP_741220.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7223233..7226707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171881.6 → NP_741220.2  Histidine kinase/HSP90-like ATPase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741220.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2L6Y6
      Conserved Domains (1) summary
      PRK05218
      Location:40 → 662
      PRK05218; heat shock protein 90; Provisional
    Nucleotide Protein
    Heading Accession and Version

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