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    gpn-1 GlyPicaN [ Caenorhabditis elegans ]

    Gene ID: 181658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpn-1
    Official Full Name
    GlyPicaN
    Primary source
    WormBase:WBGene00001687
    Locus tag
    CELE_F59D12.4
    See related
    AllianceGenome:WB:WBGene00001687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including epidermis morphogenesis; nematode larval development; and neuron migration. Predicted to be located in collagen-containing extracellular matrix and plasma membrane. Predicted to be active in cell surface. Is expressed in intestine; neuroblasts; pharynx; and ventral cord neurons. Human ortholog(s) of this gene implicated in Keipert syndrome and omodysplasia 1. Orthologous to several human genes including GPC1 (glypican 1); GPC2 (glypican 2); and GPC4 (glypican 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpn-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (15681693..15687477)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PITH domain-containing protein;Thioredoxin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GPN-1/glypican and UNC-52/perlecan do not appear to function in BMP signaling to pattern the C. elegans postembryonic mesoderm. DeGroot MS, et al. MicroPubl Biol, 2021. PMID 34405137, Free PMC Article
    2. Regulation of TGFβ superfamily signaling by two separable domains of glypican LON-2 in C. elegans. Taneja-Bageshwar S, et al. Worm, 2013 Jul 1. PMID 24778932, Free PMC Article
    3. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Gumienny TL, et al. Curr Biol, 2007 Jan 23. PMID 17240342
    4. Extracellular sugar modifications provide instructive and cell-specific information for axon-guidance choices. Bülow HE, et al. Curr Biol, 2008 Dec 23. PMID 19062279, Free PMC Article
    5. Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development. Kinnunen TK. PLoS One, 2014. PMID 25054285, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermis morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GlyPicaN
    NP_510582.1
    • Product from WormBase gene class gpn;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15681693..15687477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078181.4 → NP_510582.1  GlyPicaN [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGU4
      Conserved Domains (1) summary
      pfam01153
      Location:43 → 414
      Glypican; Glypican
    Nucleotide Protein
    Heading Accession and Version

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