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    gei-17 E3 SUMO-protein ligase gei-17 [ Caenorhabditis elegans ]

    Gene ID: 172733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gei-17
    Official Full Name
    E3 SUMO-protein ligase gei-17
    Primary source
    WormBase:WBGene00001574
    Locus tag
    CELE_W10D5.3
    See related
    AllianceGenome:WB:WBGene00001574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and SUMO ligase activity. Involved in several processes, including meiotic metaphase I homologous chromosome alignment; protein sumoylation; and regulation of cellular response to stress. Located in chromatin and metaphase plate. Is expressed in motor neurons. Orthologous to several human genes including PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gei-17 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (9100845..9107848, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MEF2 transcription factor homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Neighboring gene Poly(A) RNA polymerase gld-4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide survey and systematic RNAi-based characterization of helicase-like genes in Caenorhabditis elegans. Eki T, et al. DNA Res, 2007 Aug 31. PMID 17921522, Free PMC Article
    2. Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development. Fergin A, et al. PLoS Genet, 2022 Jun. PMID 35666766, Free PMC Article
    3. A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis. Pelisch F, et al. Mol Cell, 2017 Jan 5. PMID 27939944, Free PMC Article
    4. Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans. Davis-Roca AC, et al. PLoS Genet, 2018 Sep. PMID 30180169, Free PMC Article
    5. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Chen SY, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104385, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic metaphase I homologous chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of mitotic DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of error-prone translesion synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of error-prone translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of macromolecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in metaphase plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase gei-17
    NP_001021677.3
    • Confirmed by transcript evidence
    NP_001021678.3
    • Partially confirmed by transcript evidence
    NP_001021679.3
    • Partially confirmed by transcript evidence
    NP_492442.3
    • Confirmed by transcript evidence
    NP_492443.3
    • Confirmed by transcript evidence
    NP_492444.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9100845..9107848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026506.5 → NP_001021677.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021677.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94361
      Conserved Domains (2) summary
      pfam02891
      Location:356 → 405
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:164 → 302
      PINIT; PINIT domain

    2. NM_060043.5 → NP_492444.4  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492444.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q564X2, Q7Z0X3, Q7Z0X4, Q94361, Q94363, Q9U326
      Conserved Domains (3) summary
      pfam02891
      Location:411 → 460
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam10599
      Location:628 → 724
      Nup_retrotrp_bd; Retro-transposon transporting motif
      pfam14324
      Location:219 → 357
      PINIT; PINIT domain

    3. NM_060041.7 → NP_492442.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492442.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94361
      Conserved Domains (2) summary
      pfam02891
      Location:356 → 405
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:164 → 302
      PINIT; PINIT domain

    4. NM_060042.5 → NP_492443.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492443.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94361
      Conserved Domains (2) summary
      pfam02891
      Location:354 → 403
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:162 → 300
      PINIT; PINIT domain

    5. NM_001026507.5 → NP_001021678.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021678.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94361
      Conserved Domains (3) summary
      pfam02891
      Location:356 → 405
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam10599
      Location:573 → 669
      Nup_retrotrp_bd; Retro-transposon transporting motif
      pfam14324
      Location:164 → 302
      PINIT; PINIT domain

    6. NM_001026508.7 → NP_001021679.3  E3 SUMO-protein ligase gei-17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021679.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94361
      Conserved Domains (3) summary
      pfam02891
      Location:289 → 338
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam10599
      Location:506 → 601
      Nup_retrotrp_bd; Retro-transposon transporting motif
      pfam14324
      Location:97 → 235
      PINIT; PINIT domain

    RNA

    1. NR_000051.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94361.4

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