U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lin-59 putative histone-lysine N-methyltransferase lin-59 [ Caenorhabditis elegans ]

    Gene ID: 266825, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lin-59
    Official Full Name
    putative histone-lysine N-methyltransferase lin-59
    Primary source
    WormBase:WBGene00003040
    Locus tag
    CELE_T12F5.4
    See related
    AllianceGenome:WB:WBGene00003040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3K36 methyltransferase activity. Involved in several processes, including ectodermal cell fate specification; egg-laying behavior; and nematode male tail tip morphogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in hypodermis; intestine; muscle cell; and neurons. Used to study leukemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lin-59 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (3713449..3721157, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene pre-microRNA mir-8204 Neighboring gene PRELI/MSF1 domain-containing protein Neighboring gene ATP-dependent RNA helicase glh-4 Neighboring gene RING-type domain-containing protein Neighboring gene HTH La-type RNA-binding domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A recombineering pipeline for functional genomics applied to Caenorhabditis elegans. Sarov M, et al. Nat Methods, 2006 Oct. PMID 16990816
    2. Characterisation of set-1, a conserved PR/SET domain gene in Caenorhabditis elegans. Terranova R, et al. Gene, 2002 Jun 12. PMID 12119097
    3. A left/right asymmetric neuronal differentiation program is controlled by the Caenorhabditis elegans lsy-27 zinc-finger transcription factor. Zhang F, et al. Genetics, 2011 Jul. PMID 21555395, Free PMC Article
    4. Characterization of seven genes affecting Caenorhabditis elegans hindgut development. Chamberlin HM, et al. Genetics, 1999 Oct. PMID 10511553, Free PMC Article
    5. Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Potts MB, et al. Dev Biol, 2009 May 15. PMID 19254707

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ectodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative histone-lysine N-methyltransferase lin-59
    NP_491206.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3713449..3721157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058805.8 → NP_491206.1  putative histone-lysine N-methyltransferase lin-59 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44757
      Conserved Domains (4) summary
      smart00570
      Location:591 → 636
      AWS; associated with SET domains
      smart00317
      Location:638 → 748
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd04717
      Location:1118 → 1222
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      pfam00628
      Location:970 → 1027
      PHD; PHD-finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44757.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools