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    rbf-1 Rabphilin-1 [ Caenorhabditis elegans ]

    Gene ID: 175943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbf-1
    Official Full Name
    Rabphilin-1
    Primary source
    WormBase:WBGene00004316
    Locus tag
    CELE_F37A4.7
    See related
    AllianceGenome:WB:WBGene00004316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in dense core granule exocytosis and positive regulation of locomotion. Located in synaptic vesicle. Is expressed in dorsal nerve cord; nerve ring; neurons; and ventral nerve cord. Orthologous to several human genes including RPH3A (rabphilin 3A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rbf-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    22
    Sequence:
    Chromosome: III; NC_003281.10 (6675760..6703998)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chromatin-remodeling complex ATPase chain isw-1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3. Staunton J, et al. J Neurosci, 2001 Dec 1. PMID 11717359, Free PMC Article
    2. RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans. Feng W, et al. Sci China Life Sci, 2012 Mar. PMID 22527519
    3. Sequenced Breakpoints of Crossover Suppressor/Inversion qC1. Edgley ML, et al. MicroPubl Biol, 2021. PMID 34746683, Free PMC Article
    4. HID-1, a new component of the peptidergic signaling pathway. Mesa R, et al. Genetics, 2011 Feb. PMID 21115972, Free PMC Article
    5. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Wang Y, et al. Nature, 1997 Aug 7. PMID 9252191

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dense core granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rabphilin-1
    NP_001022566.1
    • Confirmed by transcript evidence
    NP_001022567.1
    • Confirmed by transcript evidence
    NP_001367825.1
    • Confirmed by transcript evidence
    NP_001379930.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6675760..6703998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379772.1 → NP_001367825.1  Rabphilin-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
      Conserved Domains (3) summary
      cd04035
      Location:845 → 967
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:987 → 1119
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      pfam02318
      Location:220 → 342
      FYVE_2; FYVE-type zinc finger

    2. NM_001392126.1 → NP_001379930.1  Rabphilin-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
      Conserved Domains (3) summary
      cd04035
      Location:675 → 797
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:817 → 949
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      pfam02318
      Location:50 → 172
      FYVE_2; FYVE-type zinc finger

    3. NM_001027396.5 → NP_001022567.1  Rabphilin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
      Conserved Domains (3) summary
      cd04035
      Location:684 → 806
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:826 → 958
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      pfam02318
      Location:60 → 181
      FYVE_2; FYVE-type zinc finger

    4. NM_001027395.5 → NP_001022566.1  Rabphilin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
      Conserved Domains (3) summary
      cd04035
      Location:750 → 872
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:892 → 1024
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      pfam02318
      Location:126 → 247
      FYVE_2; FYVE-type zinc finger
    Nucleotide Protein
    Heading Accession and Version

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