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    isw-1 Chromatin-remodeling complex ATPase chain isw-1 [ Caenorhabditis elegans ]

    Gene ID: 175944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    isw-1
    Official Full Name
    Chromatin-remodeling complex ATPase chain isw-1
    Primary source
    WormBase:WBGene00002169
    Locus tag
    CELE_F37A4.8
    See related
    AllianceGenome:WB:WBGene00002169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Involved in positive regulation of transcription by RNA polymerase II and positive regulation of vulval development. Located in chromatin. Is expressed in several structures, including developing hermaphrodite gonad; head; intestine; pharynx; and vulva. Orthologous to several human genes including SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See isw-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (6703988..6710100, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rabphilin-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Ankyrin repeat-containing protein F37A4.4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress. Matilainen O, et al. Nat Commun, 2017 Nov 28. PMID 29180639, Free PMC Article
    2. LSY-2 is essential for maintaining the germ-soma distinction in C. elegans. Lin L, et al. Protein Cell, 2015 Aug. PMID 26050091, Free PMC Article
    3. The miR-58 microRNA family is regulated by insulin signaling and contributes to lifespan regulation in Caenorhabditis elegans. Zhang Y, et al. Sci China Life Sci, 2018 Sep. PMID 29948901
    4. Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans. Lee J, et al. J Biol Chem, 2013 Jan 18. PMID 23229554, Free PMC Article
    5. Gene expression: long-term gene silencing by RNAi. Vastenhouw NL, et al. Nature, 2006 Aug 24. PMID 16929289

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome array spacer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chromatin-remodeling complex ATPase chain isw-1
    NP_001379931.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6703988..6710100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392127.1 → NP_001379931.1  Chromatin-remodeling complex ATPase chain isw-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41877
      Conserved Domains (1) summary
      PLN03142
      Location:48 → 1008
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41877.2

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