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    gst-10 GST C-terminal domain-containing protein;Glutathione S-transferase P 10 [ Caenorhabditis elegans ]

    Gene ID: 178725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-10
    Official Full Name
    GST C-terminal domain-containing protein;Glutathione S-transferase P 10
    Primary source
    WormBase:WBGene00001758
    Locus tag
    CELE_Y45G12C.2
    See related
    AllianceGenome:WB:WBGene00001758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables glutathione transferase activity. Involved in several processes, including determination of adult lifespan; heat acclimation; and response to hydrogen peroxide. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and tail. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); eye disease (multiple); hematopoietic system disease (multiple); and respiratory system disease (multiple). Orthologous to several human genes including GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (2561690..2564645)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene GST N-terminal domain-containing protein Neighboring gene Seven TM Receptor Neighboring gene Nucleotid_trans domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class J

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Ayyadevara S, et al. Aging Cell, 2005 Oct. PMID 16164425
    2. Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). Singh SP, et al. Aging (Albany NY), 2008 Dec 18. PMID 20157589, Free PMC Article
    3. Latilactobacillus curvatus FFZZH5L isolated from pickled cowpea enhanced antioxidant activity in Caenorhabditis elegans by upregulating the level of glutathione S-transferase. Lu H, et al. Food Funct, 2023 Sep 19. PMID 37672003
    4. Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Ayyadevara S, et al. Antioxid Redox Signal, 2013 Feb 10. PMID 22866967
    5. Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. Ayyadevara S, et al. Aging Cell, 2005 Dec. PMID 16300482

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutathione transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV-C IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GST C-terminal domain-containing protein;Glutathione S-transferase P 10
    NP_001303772.1
    • Confirmed by transcript evidence
    NP_503701.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2561690..2564645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071300.9 → NP_503701.1  Glutathione S-transferase P 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503701.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N4X8
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 196
      PTZ00057; glutathione s-transferase; Provisional
      cd03076
      Location:3 → 76
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:84 → 208
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001316843.3 → NP_001303772.1  GST C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RDX7
      Conserved Domains (1) summary
      cl02776
      Location:1 → 117
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N4X8.3

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