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    rmd-1 Regulator of microtubule dynamics protein 1 [ Caenorhabditis elegans ]

    Gene ID: 176379, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rmd-1
    Official Full Name
    Regulator of microtubule dynamics protein 1
    Primary source
    WormBase:WBGene00011501
    Locus tag
    CELE_T05G5.7
    See related
    AllianceGenome:WB:WBGene00011501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables kinase binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore and mitotic spindle organization. Located in mitotic spindle pole and spindle microtubule. Is expressed in germ line and gonadal sheath cell. Orthologous to human RMDN1 (regulator of microtubule dynamics 1); RMDN2 (regulator of microtubule dynamics 2); and RMDN3 (regulator of microtubule dynamics 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rmd-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (9759094..9760389)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative enoyl-CoA hydratase, mitochondrial Neighboring gene Vacuolar protein sorting-associated protein 53 homolog Neighboring gene GRIP and coiled-coil domain-containing protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein cbp-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paternal mitochondria from an rmd-2, rmd-3, rmd-6 triple mutant are properly positioned in the C. elegans zygote. Juanico IY, et al. MicroPubl Biol, 2021. PMID 34296068, Free PMC Article
    2. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. Oishi K, et al. J Cell Biol, 2007 Dec 17. PMID 18070910, Free PMC Article
    3. A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges. Rehain-Bell K, et al. Curr Biol, 2017 Mar 20. PMID 28285996, Free PMC Article
    4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Regulator of microtubule dynamics protein 1
    NP_001255029.1
    • Confirmed by transcript evidence
    NP_001255030.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9759094..9760389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268100.3 → NP_001255029.1  Regulator of microtubule dynamics protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255029.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2FLF5, H2FLF6, P34560
      Conserved Domains (1) summary
      sd00006
      Location:121 → 171
      TPR; TPR repeat [structural motif]

    2. NM_001268101.3 → NP_001255030.1  Regulator of microtubule dynamics protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34560
      Conserved Domains (1) summary
      sd00006
      Location:90 → 140
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34560.2

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