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    daf-28 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 191014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daf-28
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00000920
    Locus tag
    CELE_Y116F11B.1
    See related
    AllianceGenome:WB:WBGene00000920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable insulin receptor binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of dauer entry; and regulation of synaptic assembly at neuromuscular junction. Acts upstream of with a negative effect on protein import into nucleus. Located in extracellular space and synapse. Is expressed in several structures, including distal tip cell; egg-laying apparatus; neurons; pharynx; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See daf-28 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (19815133..19816442)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LITAF domain-containing protein Neighboring gene ncRNA Neighboring gene Prolyl Carboxy Peptidase like Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans. Kaplan REW, et al. BMC Biol, 2018 Oct 8. PMID 30296941, Free PMC Article
    2. Social Chemical Communication Determines Recovery From L1 Arrest via DAF-16 Activation. Mata-Cabana A, et al. Front Cell Dev Biol, 2020. PMID 33240886, Free PMC Article
    3. Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans. Ohta A, et al. Nat Commun, 2014 Jul 22. PMID 25048458, Free PMC Article
    4. A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein. Klabonski L, et al. PLoS Genet, 2016 Dec. PMID 27926939, Free PMC Article
    5. The unfolded protein response in a pair of sensory neurons promotes entry of C. elegans into dauer diapause. Kulalert W, et al. Curr Biol, 2013 Dec 16. PMID 24316205, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using functional, fluorescently-tagged protein, we find that, in animals with mutant DAF-28/IGF, the wild-type DAF-7/TGF-beta is mislocalized to and accumulates in the proximal axon of the ASI neuron. Activation of two different branches of the unfolded protein response can modulate both the developmental phenotype and DAF-7 mislocalization in DAF-28(R37C) animals, but appear to act through divergent mechanisms
      Title: A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.
    2. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
      Title: Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
    3. DAF-8 partners with the nuclear hormone receptor NHR-69, a C. elegans ortholog of mammalian hepatocyte nuclear factor 4alpha HNF4alpha), to repress the exp-2 potassium channel gene and increase insulin secretion
      Title: Repression of a potassium channel by nuclear hormone receptor and TGF-β signaling modulates insulin signaling in Caenorhabditis elegans.
    4. TRX-1 modulates DAF-28 signaling by contributing to the down-regulation of daf-28 expression during dauer formation.
      Title: The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans.
    5. conclude that mitochondrial function is required for C. elegans to secrete DAF-28/insulin when food is abundant
      Title: Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_507840.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19815133..19816442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075439.4 → NP_507840.1  Uncharacterized protein CELE_Y116F11B.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NEK7
      Conserved Domains (1) summary
      pfam03488
      Location:46 → 93
      Ins_beta; Nematode insulin-related peptide beta type
    Nucleotide Protein
    Heading Accession and Version

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