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    egrh-2 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egrh-2
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00043705
    Locus tag
    CELE_Y55F3AM.7
    See related
    AllianceGenome:WB:WBGene00043705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; asthma; and motor peripheral neuropathy. Orthologous to several human genes including EGR1 (early growth response 1) and EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egrh-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (984384..990452, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene Amidase domain-containing protein Neighboring gene Sema domain-containing protein Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase makorin Neighboring gene SPIN90/Ldb17 leucine-rich domain-containing protein Neighboring gene Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluating the adverse effects and mechanisms of nanomaterial exposure on longevity of C. elegans: A literature meta-analysis and bioinformatics analysis of multi-transcriptome data. Yin F, et al. Environ Res, 2024 Apr 15. PMID 38224941
    2. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_001294399.1
    • Partially confirmed by transcript evidence
    NP_001294400.1
    • Confirmed by transcript evidence
    NP_001368248.1
    • Partially confirmed by transcript evidence
    NP_001368249.1
    • Confirmed by transcript evidence
    NP_001379379.1
    • Partially confirmed by transcript evidence
    NP_001379380.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      984384..990452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307471.4 → NP_001294400.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBA8
      Conserved Domains (4) summary
      COG5048
      Location:205 → 272
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:180 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:178 → 202
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:222 → 247
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001307470.3 → NP_001294399.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEI2
      Conserved Domains (4) summary
      COG5048
      Location:205 → 268
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:180 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:178 → 202
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:222 → 247
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001392251.1 → NP_001379379.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SV07
      Conserved Domains (3) summary
      sd00017
      Location:180 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:178 → 202
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:222 → 247
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001380026.1 → NP_001368249.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM44
      Conserved Domains (2) summary
      COG5048
      Location:40 → 107
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:15 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001392252.1 → NP_001379380.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SUP3
      Conserved Domains (2) summary
      COG5048
      Location:40 → 104
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:15 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001380027.1 → NP_001368248.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBN9
      Conserved Domains (2) summary
      COG5048
      Location:40 → 103
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:15 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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