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    numr-2 PB1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    numr-2
    Official Full Name
    PB1 domain-containing protein
    Primary source
    WormBase:WBGene00017267
    Locus tag
    CELE_F08F8.1
    See related
    AllianceGenome:WB:WBGene00017267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in nucleus. Is expressed in intestine; sensory neurons; uterine muscle; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See numr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003281.10 (7364385..7365230)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl coenzyme A reductase Neighboring gene PB1 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response. Abraham E, et al. ACS Chem Biol, 2024 May 17. PMID 38652683,
    2. Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans. Tvermoes BE, et al. J Cell Sci, 2010 Jun 15. PMID 20501697, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUMR-1 and NUMR-2 function to promote resistance to metal-induced and to increase longevity.
      Title: Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PB1 domain-containing protein
    NP_001309499.1
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7364385..7365230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322670.1 → NP_001309499.1  PB1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19208, Q19209
    Nucleotide Protein
    Heading Accession and Version

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