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    tub-2 Tubby C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tub-2
    Official Full Name
    Tubby C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00022139
    Locus tag
    CELE_Y71G12A.3
    See related
    AllianceGenome:WB:WBGene00022139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Orthologous to human TULP4 (TUB like protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tub-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (1874008..1884196)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Secretory carrier-associated membrane protein Neighboring gene Uncharacterized protein Neighboring gene AB hydrolase-1 domain-containing protein Neighboring gene Trafficking protein particle complex subunit 10 Neighboring gene MD-2-related lipid-recognition domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antimicrobial proteins in the response to graphene oxide in Caenorhabditis elegans. Ren M, et al. Nanotoxicology, 2017 May. PMID 28490217
    2. The Muscleblind-like protein MBL-1 regulates microRNA expression in Caenorhabditis elegans through an evolutionarily conserved autoregulatory mechanism. Verbeeren J, et al. PLoS Genet, 2023 Dec. PMID 38134228, Free PMC Article
    3. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
    4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    Tubby C-terminal domain-containing protein
    NP_001293352.1
    • Confirmed by transcript evidence
    NP_490913.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1874008..1884196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058512.5 → NP_490913.2  Tubby C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490913.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL53
      Conserved Domains (4) summary
      COG2319
      Location:65 → 316
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:73 → 110
      7WD40; WD40 repeat [structural motif]
      pfam01167
      Location:795 → 852
      Tub; Tub family
      cl01546
      Location:680 → 771
      Cytochrom_B562; Cytochrome b562

    2. NM_001306423.3 → NP_001293352.1  Tubby C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LV96
      Conserved Domains (2) summary
      pfam01167
      Location:255 → 312
      Tub; Tub family
      cl01546
      Location:140 → 231
      Cytochrom_B562; Cytochrome b562
    Nucleotide Protein
    Heading Accession and Version

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