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    stam-1 Signal transducing adapter molecule 1 [ Caenorhabditis elegans ]

    Gene ID: 172264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stam-1
    Official Full Name
    Signal transducing adapter molecule 1
    Primary source
    WormBase:WBGene00004109
    Locus tag
    CELE_C34G6.7
    See related
    AllianceGenome:WB:WBGene00004109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein localization to non-motile cilium; and response to hermaphrodite contact. Located in cilium and early endosome. Part of ESCRT-0 complex. Is expressed in male gonad; neurons; and pharyngeal-intestinal valve. Used to study polycystic kidney disease. Orthologous to several human genes including STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See stam-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (5902105..5904695, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene P-GlycoProtein related Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene ShKT domain-containing protein Neighboring gene HEAT repeat protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously. Mayers JR, et al. J Biol Chem, 2011 Mar 18. PMID 21193406, Free PMC Article
    2. STAM and Hrs down-regulate ciliary TRP receptors. Hu J, et al. Mol Biol Cell, 2007 Sep. PMID 17581863, Free PMC Article
    3. UEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neurons. Kramer LB, et al. PLoS One, 2010 Dec 13. PMID 21179194, Free PMC Article
    4. Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane. Mayers JR, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818590, Free PMC Article
    5. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Govindan JA, et al. Curr Biol, 2006 Jul 11. PMID 16824915

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hermaphrodite contact IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT-0 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Signal transducing adapter molecule 1
    NP_491710.2
    • Confirmed by transcript evidence
    NP_871813.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5902105..5904695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059309.9 → NP_491710.2  Signal transducing adapter molecule 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491710.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01498, Q8I7I2
      Conserved Domains (2) summary
      cd03568
      Location:12 → 155
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      cl17036
      Location:222 → 274
      SH3; Src Homology 3 domain superfamily

    2. NM_182013.8 → NP_871813.1  Signal transducing adapter molecule 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01498
      Conserved Domains (2) summary
      cd03568
      Location:4 → 147
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      cl17036
      Location:214 → 266
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01498.2

    Gene LinkOut

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