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    afmd-1 BD-FAE-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    afmd-1
    Official Full Name
    BD-FAE-like domain-containing protein
    Primary source
    WormBase:WBGene00017051
    Locus tag
    CELE_D2024.2
    See related
    AllianceGenome:WB:WBGene00017051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in tryptophan catabolic process to kynurenine. Predicted to be active in cytoplasm. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See afmd-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (7244228..7245502)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Putative fatty acid elongase 3 Neighboring gene ncRNA Neighboring gene Glutathione s-transferase kappa 2 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BD-FAE-like domain-containing protein
    NP_501149.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7244228..7245502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068748.6 → NP_501149.1  BD-FAE-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18974
      Conserved Domains (1) summary
      COG0657
      Location:26 → 169
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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