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    C08G9.2 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 177545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C08G9.2
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00015620
    Locus tag
    CELE_C08G9.2
    See related
    AllianceGenome:WB:WBGene00015620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in head neurons and pharynx. Orthologous to several human genes including WFDC10A (WAP four-disulfide core domain 10A); WFDC10B (WAP four-disulfide core domain 10B); and WFDC11 (WAP four-disulfide core domain 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C08G9.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    26
    Sequence:
    Chromosome: IV; NC_003282.8 (7664157..7672972, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inositol 1,4,5-trisphosphate receptor itr-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_501249.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7664157..7672972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068848.4 → NP_501249.1  Uncharacterized protein CELE_C08G9.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501249.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44131
      Conserved Domains (5) summary
      smart00211
      Location:577 → 619
      TY; Thyroglobulin type I repeats
      cd00191
      Location:1705 → 1768
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00014
      Location:1946 → 1997
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:90 → 127
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam14625
      Location:1898 → 1940
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    Nucleotide Protein
    Heading Accession and Version

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