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    drsh-1 Ribonuclease 3 [ Caenorhabditis elegans ]

    Gene ID: 172830, updated on 9-Dec-2024

    Summary

    Official Symbol
    drsh-1
    Official Full Name
    Ribonuclease 3
    Primary source
    WormBase:WBGene00009163
    Locus tag
    CELE_F26E4.10
    See related
    AllianceGenome:WB:WBGene00009163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be part of microprocessor complex. Predicted to be active in nucleus. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See drsh-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (9781324..9785724, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FAS1 domain-containing protein Neighboring gene ncRNA Neighboring gene Glutathione peroxidase 1 Neighboring gene ncRNA Neighboring gene Tubulin alpha chain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene COX5B-domain-containing protein

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA endonuclease activity  
    enables endonuclease activity  
    enables metal ion binding  
    enables ribonuclease III activity  
    enables ribonuclease III activity  
    enables ribonuclease III activity PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing  
    involved_in cell differentiation  
    involved_in gonadal mesoderm development  
    involved_in miRNA processing  
    involved_in pre-miRNA processing  
    involved_in primary miRNA processing  
    involved_in primary miRNA processing PubMed 
    involved_in rRNA processing  
    involved_in ribosome biogenesis  
    involved_in sexual reproduction PubMed 
    Component Evidence Code Pubs
    part_of microprocessor complex  
    part_of microprocessor complex PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Ribonuclease 3
    NP_001122460.2
    • Confirmed by transcript evidence
    NP_492599.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9781324..9785724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128988.5 → NP_001122460.2  Ribonuclease 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122460.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01326
      Conserved Domains (3) summary
      smart00535
      Location:846 → 974
      RIBOc; Ribonuclease III family
      smart00358
      Location:983 → 1056
      DSRM; Double-stranded RNA binding motif
      PRK00102
      Location:831 → 1056
      rnc; ribonuclease III; Reviewed
    2. NM_060198.5 → NP_492599.1  Ribonuclease 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WI03, O01326, O01327, Q9U9Q8
      Conserved Domains (3) summary
      smart00535
      Location:848 → 976
      RIBOc; Ribonuclease III family
      smart00358
      Location:985 → 1058
      DSRM; Double-stranded RNA binding motif
      PRK00102
      Location:833 → 1058
      rnc; ribonuclease III; Reviewed
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