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    chk-1 Serine/threonine-protein kinase chk-1 [ Caenorhabditis elegans ]

    Gene ID: 3565921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chk-1
    Official Full Name
    Serine/threonine-protein kinase chk-1
    Primary source
    WormBase:WBGene00000498
    Locus tag
    CELE_Y39H10A.7
    See related
    AllianceGenome:WB:WBGene00000498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3T11 kinase activity. Involved in embryo development and mitotic DNA replication checkpoint signaling. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in germ line. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chk-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (3757153..3759469, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene ncRNA Neighboring gene Myotubularin-related protein 9 Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Acyltransferase 3 domain-containing protein;Nose resistant-to-fluoxetine protein N-terminal domain-containing protein Neighboring gene Dauer Up-Regulated

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline. Hornos Carneiro MF, et al. Genetics, 2020 Feb. PMID 31852725, Free PMC Article
    2. Meiotic errors activate checkpoints that improve gamete quality without triggering apoptosis in male germ cells. Jaramillo-Lambert A, et al. Curr Biol, 2010 Dec 7. PMID 20970339, Free PMC Article
    3. RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans. Merry A, et al. Biochem J, 2014 Mar 1. PMID 24262006
    4. chk-1 is an essential gene and is required for an S-M checkpoint during early embryogenesis. Kalogeropoulos N, et al. Cell Cycle, 2004 Sep. PMID 15326393
    5. A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Lee SJ, et al. Development, 2004 Jun. PMID 15115755

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase chk-1
    NP_001024234.1
    • Confirmed by transcript evidence
    NP_001380036.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3757153..3759469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392496.1 → NP_001380036.1  Serine/threonine-protein kinase chk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17375, Q86FM7, Q9N3Z3
      Conserved Domains (1) summary
      cd14069
      Location:22 → 286
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

    2. NM_001029063.4 → NP_001024234.1  Serine/threonine-protein kinase chk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024234.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N3Z3
      Conserved Domains (2) summary
      smart00220
      Location:4 → 193
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 194
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N3Z3.2

    Gene LinkOut

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