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    ptpn-22 Protein-tyrosine-phosphatase [ Caenorhabditis elegans ]

    Gene ID: 176981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptpn-22
    Official Full Name
    Protein-tyrosine-phosphatase
    Primary source
    WormBase:WBGene00021507
    Locus tag
    CELE_Y41D4A.5
    See related
    AllianceGenome:WB:WBGene00021507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to several human genes including PTPN22 (protein tyrosine phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptpn-22 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (1727963..1737884, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene CC domain-containing protein Neighboring gene Amidase domain-containing protein;Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Neighboring gene Transmembrane 9 superfamily member

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans. Binti S, et al. PLoS Genet, 2024 Aug. PMID 39173071, Free PMC Article
    2. Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans. Meng J, et al. Nat Commun, 2021 Mar 3. PMID 33658510, Free PMC Article
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans.
      Title: A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein-tyrosine-phosphatase
    NP_500128.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1727963..1737884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067727.7 → NP_500128.2  Protein-tyrosine-phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500128.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y26
      Conserved Domains (2) summary
      smart00194
      Location:102 → 365
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:129 → 365
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version

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