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    cyy-1 Cyclin-Y [ Caenorhabditis elegans ]

    Gene ID: 176188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyy-1
    Official Full Name
    Cyclin-Y
    Primary source
    WormBase:WBGene00022697
    Locus tag
    CELE_ZK353.1
    See related
    AllianceGenome:WB:WBGene00022697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase binding activity. Involved in negative regulation of synapse assembly; regulation of neuron remodeling; and regulation of terminal button organization. Located in axon and dendrite. Orthologous to several human genes including CCNY (cyclin Y) and CCNYL1 (cyclin Y like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyy-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (8405874..8409399)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Copper homeostasis protein cutC homolog Neighboring gene UBX domain-containing protein 4 Neighboring gene PITH domain-containing protein ZK353.9 Neighboring gene Sop-2-related protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optical control of cell signaling by single-chain photoswitchable kinases. Zhou XX, et al. Science, 2017 Feb 24. PMID 28232577, Free PMC Article
    2. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Ou CY, et al. Cell, 2010 May 28. PMID 20510931, Free PMC Article
    3. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Park M, et al. Neuron, 2011 May 26. PMID 21609829, Free PMC Article
    4. Neuronal sub-compartmentalization: a strategy to optimize neuronal function. Donato A, et al. Biol Rev Camb Philos Soc, 2019 Jun. PMID 30609235, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-Y
    NP_498857.2
    • Confirmed by transcript evidence
    NP_498858.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8405874..8409399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066456.6 → NP_498857.2  Cyclin-Y [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498857.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34624
      Conserved Domains (1) summary
      cl00050
      Location:163 → 284
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. NM_066457.6 → NP_498858.2  Cyclin-Y [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498858.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34624
      Conserved Domains (1) summary
      cl00050
      Location:161 → 282
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34624.3

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