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    che-10 Rootletin [ Caenorhabditis elegans ]

    Gene ID: 173801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    che-10
    Official Full Name
    Rootletin
    Primary source
    WormBase:WBGene00018051
    Locus tag
    CELE_F35D11.11
    See related
    AllianceGenome:WB:WBGene00018051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cilium assembly. Located in ciliary basal body and ciliary transition zone. Orthologous to human CEP250 (centrosomal protein 250) and CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See che-10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (4627811..4638341, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich) domain-bearing protein 25 Neighboring gene C-type lectin domain-containing protein Neighboring gene Protein quiver Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Alpha-(1,3)-fucosyltransferase fut-6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Striated rootlet and nonfilamentous forms of rootletin maintain ciliary function. Mohan S, et al. Curr Biol, 2013 Oct 21. PMID 24094853
    2. Mutations affecting microtubule structure in Caenorhabditis elegans. Chalfie M, et al. J Cell Sci Suppl, 1986. PMID 3477555
    3. Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans. Hwang HY, et al. Sci Rep, 2021 May 26. PMID 34040027, Free PMC Article
    4. Mutants of the nematode Caenorhabditis elegans that are defective specifically in their attraction to cycloheximide. Tajima T, et al. J Biosci Bioeng, 2003. PMID 16233500
    5. An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration. Sun Y, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37722038, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rootletin
    NP_001367815.1
    • Confirmed by transcript evidence
    NP_494819.3
    • Confirmed by transcript evidence
    NP_494820.3
    • Confirmed by transcript evidence
    NP_494821.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4627811..4638341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062418.8 → NP_494819.3  Rootletin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494819.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4SGS2, G4SGT1, G4SGT2, Q09EF5, Q09EF6, Q09EF7, Q8MQ60
      Conserved Domains (3) summary
      pfam15035
      Location:164 → 282
      Rootletin; Ciliary rootlet component, centrosome cohesion
      cl25732
      Location:568 → 1297
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26527
      Location:1766 → 1856
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein

    2. NM_062419.7 → NP_494820.3  Rootletin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494820.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09EF7
      Conserved Domains (4) summary
      PHA02896
      Location:411 → 592
      PHA02896; A-type inclusion like protein; Provisional
      TIGR02168
      Location:879 → 1737
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05010
      Location:577 → 781
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam15035
      Location:164 → 282
      Rootletin; Ciliary rootlet component, centrosome cohesion

    3. NM_001381398.2 → NP_001367815.1  Rootletin [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      TIGR02168
      Location:188 → 917
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033930
      Location:17 → 297
      pneumo_PspA; pneumococcal surface protein A

    4. NM_062420.7 → NP_494821.3  Rootletin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494821.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09EF7
      Conserved Domains (4) summary
      PHA02896
      Location:411 → 592
      PHA02896; A-type inclusion like protein; Provisional
      TIGR02168
      Location:879 → 1737
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05010
      Location:577 → 781
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam15035
      Location:164 → 282
      Rootletin; Ciliary rootlet component, centrosome cohesion
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09EF7.2

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