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    twf-2 ADF-H domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181711, updated on 9-Dec-2024

    Summary

    Official Symbol
    twf-2
    Official Full Name
    ADF-H domain-containing protein
    Primary source
    WormBase:WBGene00018187
    Locus tag
    CELE_F38E9.5
    See related
    AllianceGenome:WB:WBGene00018187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in actin filament depolymerization; negative regulation of actin filament polymerization; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in cytoskeleton. Predicted to be active in actin filament and myofibril. Is expressed in several structures, including enteric muscle; intestine; nervous system; pharynx; and vulval muscle. Orthologous to several human genes including TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See twf-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (16446197..16451336)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Zinc metalloproteinase nas-39 Neighboring gene ncRNA Neighboring gene tRNA-Arg

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular component biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ADF-H domain-containing protein
    NP_001379940.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16446197..16451336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392908.1NP_001379940.1  ADF-H domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20173
      Conserved Domains (2) summary
      cd11284
      Location:169304
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4138
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins