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    lmd-3 LysM domain-containing protein;Oxidation resistance protein 1 [ Caenorhabditis elegans ]

    Gene ID: 179225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmd-3
    Official Full Name
    LysM domain-containing protein;Oxidation resistance protein 1
    Primary source
    WormBase:WBGene00018700
    Locus tag
    CELE_F52E1.13
    See related
    AllianceGenome:WB:WBGene00018700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in determination of adult lifespan; response to heat; and response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Is expressed in head; hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to several human genes including OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lmd-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (8415648..8444806, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene putative V-type proton ATPase subunit H 1 Neighboring gene RNA-binding protein pos-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Post-GPI attachment to proteins factor 2 Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidation resistance 1 is essential for protection against oxidative stress and participates in the regulation of aging in Caenorhabditis elegans. Sanada Y, et al. Free Radic Res, 2014 Aug. PMID 24865925
    2. Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. SenGupta T, et al. Cell Rep, 2021 Sep 7. PMID 34496255, Free PMC Article
    3. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
    4. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LysM domain-containing protein;Oxidation resistance protein 1
    NP_001360511.1
    • Confirmed by transcript evidence
    NP_001360537.1
    • Confirmed by transcript evidence
    NP_001360538.1
    • Confirmed by transcript evidence
    NP_001367831.1
    • Confirmed by transcript evidence
    NP_001379939.1
    • Confirmed by transcript evidence
    NP_505173.2
    • Confirmed by transcript evidence
    NP_505174.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8415648..8444806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072772.4 → NP_505173.2  Oxidation resistance protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505173.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L003
      Conserved Domains (2) summary
      smart00584
      Location:666 → 838
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:24 → 66
      LysM; LysM domain

    2. NM_001373062.3 → NP_001360511.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXA9
      Conserved Domains (2) summary
      smart00584
      Location:658 → 830
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:14 → 56
      LysM; LysM domain

    3. NM_001373063.2 → NP_001360537.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WTT8
      Conserved Domains (2) summary
      smart00584
      Location:645 → 817
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:3 → 45
      LysM; LysM domain

    4. NM_001373064.1 → NP_001360538.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WX74
      Conserved Domains (2) summary
      smart00584
      Location:647 → 819
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:3 → 45
      LysM; LysM domain

    5. NM_001392562.1 → NP_001379939.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L004, Q7M3K6
      Conserved Domains (1) summary
      smart00584
      Location:266 → 438
      TLDc; domain in TBC and LysM domain containing proteins

    6. NM_072773.7 → NP_505174.3  Oxidation resistance protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505174.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SHJ1, G4SNG9, Q3Y409
      Conserved Domains (2) summary
      smart00584
      Location:656 → 828
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:14 → 56
      LysM; LysM domain

    7. NM_001380707.1 → NP_001367831.1  LysM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L005
      Conserved Domains (1) summary
      pfam01476
      Location:24 → 66
      LysM; LysM domain
    Nucleotide Protein
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