skn-1 BZIP domain-containing protein;Protein skinhead-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: skn-1
Official Full Name: BZIP domain-containing protein;Protein skinhead-1
Primary source: WormBase:WBGene00004804
Locus tag: CELE_T19E7.2
See related: AllianceGenome:WB:WBGene00004804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables Hsp70 protein binding activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; endoplasmic reticulum unfolded protein response; and positive regulation of macromolecule biosynthetic process. Located in endoplasmic reticulum; mitochondrion; and nucleus. Is expressed in several structures, including AB; C; germ line; head ganglion; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to several human genes including NFE2L1 (NFE2 like bZIP transcription factor 1); NFE2L2 (NFE2 like bZIP transcription factor 2); and NFE2L3 (NFE2 like bZIP transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See skn-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (5651039..5660384, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.
Title: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.
Abalone peptide increases stress resilience and cost-free longevity via SKN-1-governed transcriptional metabolic reprogramming in C. elegans.
Title: Abalone peptide increases stress resilience and cost-free longevity via SKN-1-governed transcriptional metabolic reprogramming in C. elegans.
The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2.
Title: The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2.
The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans.
Title: The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans.
Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.
Title: Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.
Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
Title: Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults.
Title: Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults.
Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
Title: Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.
Title: Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.
Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans.
Title: Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T19E7.2 (e-PCR)
- UniSTS:315019

T19E7.1 (e-PCR)
- UniSTS:317093

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATF6-mediated unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in IRE1-mediated unfolded protein response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesendoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to manganese ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to paraquat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to superoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BZIP domain-containing protein;Protein skinhead-1

NP_001367379.1

Confirmed by transcript evidence

NP_001368358.1

Confirmed by transcript evidence

NP_741404.1

Confirmed by transcript evidence

NP_741406.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5651039..5660384 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171345.6 → NP_741404.1 Protein skinhead-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741404.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34707, Q8MPW2, Q8MPW3

Conserved Domains (1) summary

cl21462
Location:588 → 614

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_171347.7 → NP_741406.1 Protein skinhead-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741406.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34707

Conserved Domains (1) summary

cl21462
Location:275 → 301

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001380237.1 → NP_001367379.1 Protein skinhead-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl21462
Location:498 → 524

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001380238.1 → NP_001368358.1 BZIP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLA3

Conserved Domains (1) summary

cl21462
Location:188 → 214

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain