adt-2 A disintegrin and metalloproteinase with thrombospondin motifs adt-2;Peptidase M12B domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adt-2
Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs adt-2;Peptidase M12B domain-containing protein
Primary source: WormBase:WBGene00000083
Locus tag: CELE_F08C6.1
See related: AllianceGenome:WB:WBGene00000083
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metalloendopeptidase activity. Involved in several processes, including collagen fibril organization; determination of adult lifespan; and regulation of cell size. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in socket cell and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See adt-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (7586209..7595416)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08C6.1 (e-PCR)
- UniSTS:312252

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs adt-2;Peptidase M12B domain-containing protein

NP_001024532.2

Confirmed by transcript evidence

NP_001361970.1

Confirmed by transcript evidence

NP_001367660.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7586209..7595416

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029361.5 → NP_001024532.2 A disintegrin and metalloproteinase with thrombospondin motifs adt-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024532.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19204, Q8IU50

Conserved Domains (3) summary

smart00209
Location:969 → 1015

TSP1; Thrombospondin type 1 repeats

pfam01562
Location:52 → 163

Pep_M12B_propep; Reprolysin family propeptide

cl00064
Location:211 → 417

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
NM_001375070.2 → NP_001361970.1 Peptidase M12B domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z291

Conserved Domains (4) summary

smart00209
Location:866 → 910

TSP1; Thrombospondin type 1 repeats

pfam01562
Location:40 → 163

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:433 → 502

ADAM_CR_2; ADAM cysteine-rich domain

cl00064
Location:211 → 417

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
NM_001381025.1 → NP_001367660.1 A disintegrin and metalloproteinase with thrombospondin motifs adt-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z292

Conserved Domains (1) summary

smart00209
Location:74 → 120

TSP1; Thrombospondin type 1 repeats