B0001.4 putative uridine-cytidine kinase;uridine/cytidine kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: B0001.4
Official Full Name: putative uridine-cytidine kinase;uridine/cytidine kinase
Primary source: WormBase:WBGene00007089
Locus tag: CELE_B0001.4
See related: AllianceGenome:WB:WBGene00007089
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity; cytidine kinase activity; and uridine kinase activity. Predicted to be involved in CMP biosynthetic process; CTP salvage; and UMP salvage. Predicted to be active in cytoplasm. Orthologous to several human genes including UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See B0001.4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (12135074..12138193, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0001.4 (e-PCR)
- UniSTS:317805

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables uridine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative uridine-cytidine kinase;uridine/cytidine kinase

NP_001355517.1

Partially confirmed by transcript evidence

NP_502304.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12135074..12138193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001368445.2 → NP_001355517.1 uridine/cytidine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3P6N643

Conserved Domains (1) summary

cd02023
Location:10 → 214

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
NM_069903.6 → NP_502304.2 putative uridine-cytidine kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502304.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17413

Conserved Domains (2) summary

COG0572
Location:1 → 223

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:10 → 216

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...