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    acl-14 Phospholipid/glycerol acyltransferase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acl-14
    Official Full Name
    Phospholipid/glycerol acyltransferase domain-containing protein
    Primary source
    WormBase:WBGene00019465
    Locus tag
    CELE_K07B1.5
    See related
    AllianceGenome:WB:WBGene00019465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; intestine; pharynx; reproductive system; and tail. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acl-14 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (9327214..9333062, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein Neighboring gene Acyltransferase Neighboring gene UnCoupling Protein (mitochondrial substrate carrier) Neighboring gene Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans. Ma X, et al. J Hazard Mater, 2022 Jan 5. PMID 34325294
    2. Reverse genetic screening during L1 arrest reveals a role of the diacylglycerol kinase 1 gene dgk-1 and sphingolipid metabolism genes in sleep regulation. Koutsoumparis A, et al. Genetics, 2023 Oct 4. PMID 37682641
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipid/glycerol acyltransferase domain-containing protein
    NP_001371003.1
    • Confirmed by transcript evidence
    NP_505412.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9327214..9333062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073011.9 → NP_505412.2  Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505412.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01882
      Conserved Domains (2) summary
      cd07990
      Location:89 → 322
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:315 → 369
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001383368.2 → NP_001371003.1  Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXW2
      Conserved Domains (2) summary
      cd07990
      Location:91 → 324
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:317 → 389
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein
    Heading Accession and Version

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