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    let-858 Pre-mRNA-splicing factor CWC22 homolog [ Caenorhabditis elegans ]

    Gene ID: 174689, updated on 9-Dec-2024

    Summary

    Official Symbol
    let-858
    Official Full Name
    Pre-mRNA-splicing factor CWC22 homolog
    Primary source
    WormBase:WBGene00002957
    Locus tag
    CELE_F33A8.1
    See related
    AllianceGenome:WB:WBGene00002957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in gastrulation and germ-line stem cell division. Located in chromatin; germ cell nucleus; and nucleoplasm. Is expressed in somatic cell. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See let-858 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (11022370..11027906)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Pre-mRNA-splicing factor CWC22 homolog
    NP_496363.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11022370..11027906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063962.9NP_496363.1  Pre-mRNA-splicing factor CWC22 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17336
      Conserved Domains (2) summary
      smart00543
      Location:195382
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02847
      Location:486592
      MA3; MA3 domain