dpy-21 Lysine-specific demethylase 9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpy-21
Official Full Name: Lysine-specific demethylase 9
Primary source: WormBase:WBGene00001080
Locus tag: CELE_Y59A8B.1
See related: AllianceGenome:WB:WBGene00001080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Orthologous to several human genes including RSBN1L (round spermatid basic protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dpy-21 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (17936282..17949193, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure and the activity of the dosage compensation complex (DCC) subunit DPY-21 define a Jumonji demethylase subfamily that converts H4K20me2 to H4K20me1 in worms and mammals; Unexpectedly, DPY-21 also associates with autosomes of germ cells in a DCC-independent manner to enrich H4K20me1 and trigger chromosome compaction.
Title: Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.
data suggest non-canonical, negative regulation of growth and reproduction by DPY-21 via DCC, SET-1 and SET-4 downstream of TORC2 in C. elegans.
Title: A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y59A8A.a (e-PCR)
- UniSTS:323163

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Lysine-specific demethylase 9

NP_001024266.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

17936282..17949193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029095.4 → NP_001024266.1 Lysine-specific demethylase 9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024266.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GRZ3

Conserved Domains (2) summary

pfam09736
Location:395 → 440

Bud13; Pre-mRNA-splicing factor of RES complex

cl28087
Location:433 → 666

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]