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    sma-9 Transcription factor sma-9 [ Caenorhabditis elegans ]

    Gene ID: 181271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sma-9
    Official Full Name
    Transcription factor sma-9
    Primary source
    WormBase:WBGene00004862
    Locus tag
    CELE_T05A10.1
    See related
    AllianceGenome:WB:WBGene00004862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to heat. Located in nucleus. Is expressed in several structures, including anal region; digestive tract; excretory cell; hypodermis; and vulva. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Orthologous to human HIVEP1 (HIVEP zinc finger 1); HIVEP2 (HIVEP zinc finger 2); and HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sma-9 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (10769282..10782973)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Apple domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene CLaudin-like in Caenorhabditis Neighboring gene Transthyretin-like family protein Neighboring gene SCP domain-containing protein Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri generates a short transcript that provides tissue-specific function in BMP signaling. Yin J, et al. BMC Mol Biol, 2010 Jun 17. PMID 20565799, Free PMC Article
    2. SMAD Transcription Factor, Sma-9, Attunes TGF-β Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans. Haque R, et al. Mol Neurobiol, 2016 Jan. PMID 25407930
    3. The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm. Shen Q, et al. Dev Biol, 2018 Jan 1. PMID 29155044, Free PMC Article
    4. SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans. DeGroot MS, et al. PLoS Biol, 2023 Aug. PMID 37590248, Free PMC Article
    5. The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development. Amin NM, et al. Development, 2010 May. PMID 20335356, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sma-9, attunes TGF-beta signaling cascade towards modulating amyloid beta aggregation
      Title: SMAD Transcription Factor, Sma-9, Attunes TGF-β Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans.
    2. The trans-splicing transcript encodes a C-terminal SMA-9 isoform that provide transcriptional activation activity, while full length isoforms mediate transcriptional repression and/or activation in a context-dependent manner.
      Title: Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri generates a short transcript that provides tissue-specific function in BMP signaling.
    3. Results suggest that the LIN-12/Notch pathway and the Sma/Mab TGFbeta pathway function independently in regulating dorsoventral patterning of the M lineage, with SMA-9 antagonism of TGFbeta signaling required for dorsal M lineage fates.
      Title: Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGFbeta signaling.
    4. SMA-9 antagonizes the TGFbeta signaling pathway during mesodermal patterning.
      Title: An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGFbeta signaling during mesodermal patterning.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor sma-9
    NP_001361884.1
    • Partially confirmed by transcript evidence
    NP_001361885.1
    • Confirmed by transcript evidence
    NP_001361886.1
    • Partially confirmed by transcript evidence
    NP_001361887.1
    • Partially confirmed by transcript evidence
    NP_001361888.1
    • Partially confirmed by transcript evidence
    NP_001361889.1
    • Partially confirmed by transcript evidence
    NP_001361905.1
    • Confirmed by transcript evidence
    NP_001364627.1
    • Partially confirmed by transcript evidence
    NP_001364832.1
    • Partially confirmed by transcript evidence
    NP_001380177.1
    • Partially confirmed by transcript evidence
    NP_741896.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10769282..10782973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375124.1 → NP_001361885.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      sd00017
      Location:1242 → 1264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:899 → 919
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:897 → 919
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:911 → 936
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001375119.3 → NP_001361905.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      sd00017
      Location:1639 → 1661
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1296 → 1316
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1294 → 1316
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1308 → 1333
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001377619.1 → NP_001364627.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6TPG6

    4. NM_171771.6 → NP_741896.2  Transcription factor sma-9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741896.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22190
      Conserved Domains (3) summary
      sd00017
      Location:1616 → 1638
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1273 → 1293
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1285 → 1310
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001392838.1 → NP_001380177.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      sd00019
      Location:1341 → 1361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1339 → 1361
      zf-C2H2; Zinc finger, C2H2 type

    6. NM_001375121.3 → NP_001361888.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      sd00017
      Location:1792 → 1814
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1449 → 1469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1447 → 1469
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1461 → 1486
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001375120.2 → NP_001361887.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A5T0BWQ3, A0A5T0C5A1, A0A679M2I6, B5U8M3, G5ED62, Q22190, Q7JM42, Q7JM43, Q7JM44, Q7JM45, Q7JM48
      Conserved Domains (3) summary
      sd00017
      Location:1792 → 1814
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1449 → 1469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1447 → 1469
      zf-C2H2; Zinc finger, C2H2 type

    8. NM_001375122.2 → NP_001361889.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      sd00017
      Location:1792 → 1814
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1449 → 1469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1447 → 1469
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1461 → 1486
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001375123.1 → NP_001361886.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      sd00017
      Location:1792 → 1814
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1449 → 1469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1447 → 1469
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1461 → 1486
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001377620.1 → NP_001364832.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      sd00017
      Location:1684 → 1706
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1341 → 1361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1339 → 1361
      zf-C2H2; Zinc finger, C2H2 type

    11. NM_001375125.3 → NP_001361884.1  Transcription factor sma-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6TPG1
      Conserved Domains (3) summary
      sd00017
      Location:332 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:242 → 262
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1 → 26
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JM44.2

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